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Metformin decreases angiogenesis via NF-kappa B and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1
Tan, Bee K..  Cardiovascular Research.  v. Vol.83. no. No.3.   2009-08-01. p. 566 - 574... issn: 0008-6363 .   

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