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A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated
Männikkö, Roope.  The Journal of Physiology.  v. 589. no. 13.   2011. p. 3071 - 3083... issn: 0022-3751 .   

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