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The maid of the Bridal Room by Andrea Mantegna (1431–1506) shows evidence of hypopituitary dwarfism and neurofibromatosis type-1
Raffaella, Bianucci.  Journal of the Neurological Sciences.  v. 380.   2017-09-15. p. 148 - 150... issn: 0022-510X .   

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