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Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration-resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: a double-blind, placebo-controlled, randomized Phase II trial
James, Nicholas D..  BJU International.  v. 106. no. 7.   2010. p. 966 - 973... issn: 1464-1603 .   

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